Captain America (Classic) - Defeat 50 enemies as Captain America after choosing Anti-Reg.
Daredevil (Secret War) - Defeat 50 enemies as Daredevil after choosing Pro or Anti-Reg.
Deadpool (Unmasked) - Defeat 50 enemies as Deadpool after choosing Pro-Reg.
Gambit (Horseman of the Apocalypse) - Defeat 50 enemies as Gambit after choosing Pro or Anti-Reg.
Green Goblin (Hob Goblin) - Defeat 50 enemies as Green Goblin after choosing Pro or Anti-Reg.
Hulk (Red) - Defeat 50 enemies as Hulk.
Human Torch (Ultimate) - Defeat 50 enemies as Human Torch after choosing Anti-Reg.
Iceman (Bobby Drake) - Defeat 50 enemies as Iceman after choosing Pro or Anti-Reg.
Invisible Woman (Ultimate) - Defeat 50 enemies as Invisible Woman after choosing Anti-Reg.
Iron Fist (Bei Bang-Wen) - Defeat 50 enemies as Iron Fist after choosing Anti-Reg.
Iron Man (Classic) - Defeat 50 enemies as Iron Man after choosing Pro-Reg.
Jean Grey (Marvel Girl) - Defeat 50 enemies as Jean Grey.
Luke Cage (Secret War) - Defeat 50 enemies as Luke Cage after choosing Anti-Reg.
Mr. Fantastic (Ultimate) - Defeat 50 enemies as Mr. Fantastic after choosing Pro-Reg.
Ms. Marvel (Warbird) - Defeat 50 enemies as Ms. Marvel after choosing Pro-Reg.
Penance (No Costume) - Defeat 50 enemies as Penance.
Songbird (Screaming Mimi) - Defeat 50 enemies as Songbird after choosing Pro-Reg.
Spider-Man (Iron Spider) - Defeat 50 enemies as Spider-Man after choosing Pro-Reg.
Storm (Astonishing) - Defeat 50 enemies as Storm after choosing Pro or Anti-Reg.
Thing (Ultimate) - Defeat 50 enemies as Thing after choosing Pro or Anti-Reg.
Thor (Reborn) - Defeat 50 enemies as Thor after unlocking.
Venom (Eddie Brock) - Defeat 50 enemies as Venom.
Wolverine (Secret War) - Defeat 50 enemies as Wolverine after choosing Anti-Reg.